Whether the neurochemicals are associated with the vulnerability of bipolar disorder has not been studied before, findings of which may extend our understanding of neurobiological factors associated with the pathogenesis. In this study, a cohort of bipolar offsprings were enrolled and later divided into two symptomatic (converters) and healthy bipolar offspring (non-converters). Baseline MRS data was obtained and examined in predicting the disorder conversion. The measures of mI, Cr and Cho in the left VLPFC achieved the highest prediction accuracy, which indicated that some specific neurochemicals are associated with the vulnerability of bipolar disorder.
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