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Abstract #2711

Towards Validating Structural Connectivity in the Human Language System: an Intraoperative Cortico-Cortical Stimulation Experiment

Patryk Filipiak1, Fabien Almairac2, Théodore Papadopoulo1, Denys Fontaine2, Lydiane Mondot2, Stéphan Chanelet2, Maxime Descoteaux3, Rachid Deriche1, Maureen Clerc1, and Demian Wassermann1,4

1INRIA Sophia Antipolis-Méditerranée, Université Côte d'Azur, Valbonne, France, 2Centre Hospitalier Universitaire de Nice, Université Côte d'Azur, Nice, France, 3Sherbrooke Connectivity Imaging Lab (SCIL), University of Sherbrooke, Sherbrooke, QC, Canada, 4INRIA, CEA, Université Paris-Saclay, Paris, France

We validate structural connectivity measures based on diffusion MRI with Electrical Stimulation (ES) of the human brain cortex. For this, we combine white matter fiber tractography with propagation of Cortico-Cortical Evoked Potentials (CCEPs) induced by intrasurgical ES in the language system of brain tumor patients. Our results show high correlation (Pearson's coefficient 0.5-0.9) between delays of CCEPs and pathways connecting stimulation sites with recording electrodes. Our approach outperforms earlier study based on Diffusion Tensor Imaging. This potentially indicates that probabilistic tractography is an effective tool to quantify cortico-cortical communication non-invasively.

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