The
neurobiological underpinnings of anorexia nervosa (AN) remain unclear. Altered
white matter microarchitecture has been described, but findings are
inconclusive. To investigate a statistical consensus among published DTI studies
of altered white matter microarchitecture in AN, we conducted a quantitative
voxel-based meta-analysis of fractional anisotropy using Seed-based d Mapping.
The pooled results in AN showed robust reduction fractional anisotropy in the
interhemispheric connections, frontal-subcortical circuitry and limbic association fibers. This study
provides a thorough profile of WM microarchitecture alterations in patients
with AN and these intrinsic alterations may aid in developing effective
treatments in AN.
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