HIV-infection may cause HIV-associated neurocognitive disorder. Here, factor analysis is applied to atlas-segmented brain MRSI data from a cohort of HIV-positive subjects to evaluate the relationships of MRSI measures with neuropsychological test performance and immunologic markers. Results indicate that distribution of NAA in right-hemisphere brain regions of basal ganglia, thalamus, etc. may be positively correlated with CD4 counts, and distribution of Cho in both hemispheres of similar regions positively correlated with CD8 counts in HIV-infected subjects. Higher neuropsychological z-scores tends to be associated with higher NAA and/or lower Cho distributions in specific brain regions.