Abstract #2804

Investigation of microstructural differences in the nigrosome-1 region of the substantia nigra between healthy and Parkinson’s disease subjects at 7T

Yiming Xiao¹, Jonathan C Lau^1,2, Terry M Peters^1,2,3, and Ali R Khan^1,2,3,4

¹Imaging Research Laboratories, Robarts Research Institute, Western University, London, ON, Canada, ²School of Biomedical Engineering, Western University, London, ON, Canada, ³Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ⁴The Brain and Mind Institute, Western University, London, ON, Canada

The loss of hyperintense signals of the nigrosome-1 region within the substantia nigra on T2*w MRI has previously been investigated as a potential biomarker for Parkinson’s disease (PD). Although the radiological observation is expected to be induced by microstructural changes, which can provide more insights into the mechanisms of PD, no relevant MRI studies have been conducted so far. With ultra-high-field 7T MRI, we compared the microstructural features of the nigrosome-1 regions between healthy and PD subjects using quantitative MRI, and revealed alterations in T1, R2*, mode of anisotropy, and fractional anisotropy within this subregion due to the disease.

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