We retrospectively studied 33 consecutive patients with a diagnosis of GBM or PCNSL performed both DCE and DSC imaging. The rCBV of GBM are significantly larger, and Ktrans of GBM was significantly lower than that of PCNSL in CE ROIs. There was no significant difference between two tumors in CE ROI about other DCE parameters, Ve, Vp Kep and surrounding ROIS. The ROC analysis performed with respect to the GBM and PCNSL groups revealed that 90% tile rCBV and 50% tile of Ktrans showed the largest area under the curve (AUC) of 0.949 and 0.815, respectively. PCNSL can be differentiated from GBM with rCBV value and Ktrans. rCBV was superior to Ktrans in differentiating two tumors and Ktrans had no additional value in differentiating these tumors.