Retinoblastomas (RB) with postlaminar optic nerve invasion (PLONI) increases the risk for systemic metastasis or local recurrence. MRI is the only method to detect the PLONI in patients with eye-saving treatment strategies. But accuracy of MRI in identifying PLONI was relatively limited. Radiomics is an emerging field with a number of different uses being proposed. We hypothesized that radiomics can have an additional contribution to predicting PLONI in patients with retinoblastoma. This study validated our hypothesis.