Magnetic resonance neurography (MRN) has become a widely used non-invasive tool for assessing the lumbar plexus with application to inflammatory, neoplastic, metabolic and traumatic pathologic conditions. Given that the main pathological process involved in the majority of these neurological conditions results in the alteration of myelin content, this pilot study proposes and demonstrates in healthy controls the feasibility of using MRN to facilitate reliable measurements of magnetisation transfer ratio, a biophysically meaningful MR biomarker, which has been shown to be directly influenced by the amount of myelin in neural tissue.
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