Traumatic Cervical Spinal Cord Injury (tSCI) and non-traumatic Cervical Spondylotic Myelopathy (CSM) present a focal damage to the cervical cord with different time profile. Myelin and axonal loss occurs in SCI and CSM; however, little is known how these neurodegenerative changes are comparable in both groups. Therefore, we applied T2*-weighted and DTI MRI at the cervical cord to compare macro/microstructural changes in CSM and tSCI. While the macrostructural changes were similar in both groups, DTI detected more microstructural changes in SCI. Time-dependent compensatory mechanism in CSM might account for less neurodegeneration and better clinical function compared to tSCI.