The study was performed to determine whether progression probabilities (PP) from DTI and DSC parameters can aid in differentiating glioblastomas with true-progression (TP) from pseudo-progression (PsP). MRI data from thirty-nine patients were included. All patients underwent at least two MR scans before pathological confirmation. TP patients tended to have high baseline PP values compared with PsP patients. An increase of PP of more than 25% at follow-up scans was noted in 12/15 TP patients, whereas stable or decreased PP were observed in 21/24 PsP patients. These results indicate that monitoring changes in PP values may aid in identifying TP.