Abstract #2926

Is cerebral blood flow affected by preventable neurovascular risk factors and physical fitness level?

Lisa A van der Kleij¹, Nina L. Højland Reislev², Christian S. Eriksen^3,4, Hartwig R. Siebner², Carl-Johan Boraxbekk², Erik L. Mortensen^4,5, Jeroen Hendrikse¹, Michael Kjaer^3,4, Esben T Petersen², and Ellen Garde^2,4,5

¹Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ²Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, ³Department of Orthopedic Surgery M, Institute of Sports Medicine Copenhagen, Bispebjerg and Frederiksberg University Hospitals, Copenhagen, Denmark, ⁴Centre for Healthy Aging, Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark, ⁵Department of Public Health, Copenhagen University, Copenhagen, Denmark

The health-related effects of aging (biological age) are highly variable across individuals with a similar chronological age. In this study we investigate the relationship between neurovascular health, physical fitness and mean gray matter cerebral blood flow (CBF) in a cohort of 300 home-dwelling volunteers between 62 and 70 years old. In these population-based elderly participants we found that preventable risk factors for neurovascular disease are associated with cerebral blood flow. A high mean arterial pressure, high cholesterol and low creatinine were associated with a decreased gray matter perfusion, whereas physical fitness was not.

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