Abstract #2933

Inaccurate Visualisation of Haemorrhagic Markers in Cerebral Amyloid Angiopathy in Susceptibility Weighted Imaging can be Overcome Using Susceptibility Mapping

Barbara Dymerska¹, Gargi Banerjee², Emma Dixon¹, Emma Biondetti¹, Anna Barnes³, Jonathan Schott⁴, Nick Fox⁴, Rolf Jager⁵, Karin Shmueli¹, David Werring², and David L. Thomas^2,6

¹Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ²Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ³Institute of Nuclear Medicine, University College London, London, United Kingdom, ⁴Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ⁵Lysholm Department of Neuroradiology and the Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, ⁶Leonard Wolfson Experimental Neurology Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom

Cerebral amyloid angiopathy is a small vessel disease characterised by imaging signatures including cerebral microbleeds and cortical superficial siderosis. We show here that non-local phase effects affecting Susceptibility Weighted Imaging (SWI) cause broadening and/or duplication of microbleeds, as well as deformation of superficial siderosis. Furthermore, susceptibility maps and “true SWI”, where local susceptibility values are used, facilitate more accurate microbleed size estimation, reduce the risk of microbleed miscount and provide better delineation of superficial siderosis. Therefore, susceptibility maps and true SWI are likely to be more accurate than SWI in identifying and grading these haemorrhagic markers, with potential clinical relevance.

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