Abstract #2985

Whole brain myelin imaging using a Double Echo Sliding Inversion Recovery ultrashort echo time (DESIRE-UTE) magnetic resonance imaging

Ya-Jun Ma¹, Hyungseok Jang¹, Adam Searleman¹, Eric Y Chang^1,2, Jody Corey-Bloom³, Graeme M Bydder¹, and Jiang Du¹

¹Radiology, University of California, San Diego, San Diego, CA, United States, ²VA San Diego Healthcare System, San Diego, CA, United States, ³Neurosciences, University of California, San Diego, San Diego, CA, United States

To image myelin in brain more robustly on clinical scanners, we propose a Double Echo Sliding Inversion Recovery ultrashort echo time (DESIRE-UTE) technique for volumetric myelin imaging in vivo. A series of images with different T1 contrasts can be generated by a single scan. The images with a best signal nulling of long T2 components can be easily found in the second echo image series with a minimum long T2 signals. Then myelin images were generated by dual-echo subtraction for both volunteer and multiple sclerosis (MS) patients. The myelin imaging show clearly signal loss in MS lesions in patient study.

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