To image myelin in brain more robustly on clinical scanners, we propose a Double Echo Sliding Inversion Recovery ultrashort echo time (DESIRE-UTE) technique for volumetric myelin imaging in vivo. A series of images with different T1 contrasts can be generated by a single scan. The images with a best signal nulling of long T2 components can be easily found in the second echo image series with a minimum long T2 signals. Then myelin images were generated by dual-echo subtraction for both volunteer and multiple sclerosis (MS) patients. The myelin imaging show clearly signal loss in MS lesions in patient study.