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Abstract #3001

QSM Detects Post-Concussion Changes in Subcortical Gray Matter Susceptibility

Kevin Koch1, Brad Swearingen2, Robin Karr1, Andrew Nencka1, L. Tugan Muftuler2, Timothy Meier2, and Michael McCrea2

1Radiology, Medical College of Wisconsin, Milwaukee, WI, United States, 2Neurosurgergy, Medical College of Wisconsin, Milwaukee, WI, United States

A longitudinal QSM study of sports concussion in 80 injured and control athletes is presented. Regional ROI analysis demonstrated group susceptibility effects that reproduced a previous smaller cohort study finding that QSM diffusely increased in the white matter after sports concussion. In addition, this larger cohort study identified a significant acute trend of decreased susceptibility in sub-cortical gray matter, which is indicative of the calcium influx that is known to occur during the neurometabolic cascade following brain injury. The subcortical gray matter QSM decrease correlated strongly with clinical injury severity metrics.

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