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Abstract #3010

TBI-induced alterations in white matter microstructure relate to impairments in cognition and psychological functioning

Jose Manuel Guerrero Gonzalez1, Benjamin Yeske2, Nagesh Adluru2, Gregory Kirk2, Peter Ferrazzano3, and Andrew Alexander4

1Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 2Waisman Center, University of Wisconsin - Madison, Madison, WI, United States, 3Pediatrics, Univesity of Wisconsin - Madison, Madison, WI, United States, 4University of Wisconsin - Madison, Madison, WI, United States

Diffusion tensor imaging (DTI) was performed one-two years after severe traumatic brain injury in a cohort of pre-adolescent and adolescent children. The study investigated the relationships between DTI measures and variations in performance for memory and executive function, and overall clinical dysfunction. Mean diffusivity (MD) in the fornix correlated with learning and verbal tasks. MD in the corpus callosum and global white matter was related to global fuction.

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