Objective: To evaluate the potential correlation between the clinical predictors of hypoxic ischemic encephalopathy (HIE) and R2* relaxation rate, and the correlation between R2* and radial diffusivity (RD), axial diffusivity (AD). Methods: We obtained mean R2*, RD and AD within the whole white matter of 19 term infants with clinical diagnosis of HIE and 12 healthy controls. Results: R2*, RD and AD did not differ significantly between the healthy controls and infants with HIE. R2* did not associate with the clinical predictors of HIE. Reduced R2* was correlated with increased RD and AD. Conclusion: R2*, RD and AD do not show a clear relationship with clinically defined HIE.