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Abstract #3025

R2* relaxation rate of white matter in neonates and correlation with clinical predictors of hypoxic ischemic encephalopathy

Yuting Zhang1, Alexander Rauscher2, and Alexander Mark Weber2

1Children’s Hospital of Chongqing Medical University, Chongqing, China, 2UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada

Objective: To evaluate the potential correlation between the clinical predictors of hypoxic ischemic encephalopathy (HIE) and R2* relaxation rate, and the correlation between R2* and radial diffusivity (RD), axial diffusivity (AD). Methods: We obtained mean R2*, RD and AD within the whole white matter of 19 term infants with clinical diagnosis of HIE and 12 healthy controls. Results: R2*, RD and AD did not differ significantly between the healthy controls and infants with HIE. R2* did not associate with the clinical predictors of HIE. Reduced R2* was correlated with increased RD and AD. Conclusion: R2*, RD and AD do not show a clear relationship with clinically defined HIE.

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