Dilated Virchow Robin spaces (dVRs) are common in febrile seizure (FS) patients. However, little is known about how dVRs affect the white matter structure in developing brains. This study aimed to characterize the anisotropy alterations in white matter associated with dVRs in simple FS children by using fractional anisotropy (FA). Through inter-group comparisons, FA was larger in simple FS with dVRs children than that in FS without dVRs and control groups. Significant positive correlations between FA and VRs count, seizure duration were found. These results suggest that dVRs can affect the structure of white matter by increasing FA values.