Abstract #3054

Assessment of dilated perivascular spaces in Alzheimer’s patient and normal aging using 3.0T MR images

Anuja Pradhan¹, Martha Singh¹, Tafawa Habib¹, Mustafa Salimeen¹, Xianjun Li¹, Miaomiao Wang¹, Congcong Liu¹, Quqiu Min², Guanyu Yang³, and Jian Yang^1,4

¹The first affiliated hospital of Xi'an Jiaotong University, Xi'an, China, ²Department of neurology, The first affiliated hospital of Xi’an Jiaotong University, Xi'an, China, ³Xi’an AccuRad network and technology Co. Ltd., Xi’an, China, Xi'an, China, ⁴The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiao tong University, Xi’an, Shaanxi 710049, People’s Republic of China, xi'an, China

Assessment of frequently enlarged perivascular space (EPVS) is essential for assessing Alzheimer’s disease (AD) patients. Recently, EPVS density has been found to be related to the early diagnosis of mild cognitive impairment. However, characteristics of the EPVS density in AD patients are not well understood. We evaluated 44 AD patients and 40 controls by assessing the frequency and density of EPVS in quantitative and semi-quantitative methods. The density and frequency of EPVS is higher in AD patients than that in controls. These results suggest that EPVS density could be used as an indicator in the assessment of EPVS in AD.

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