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Abstract #3092

Prospective Evaluation of Wave-CAIPI Susceptibility-Weighted Imaging (SWI) Compared to Conventional 3D SWI in a Clinical Setting

John Conklin1, Maria Gabriela Longo1, Stephen Cauley2, Kawin Setsompop2, John Kirsch 1, Wei Liu3, Sinyeob Ahn4, Thomas Beck5, Ramon Gonzalez1, Pamela Schaefer1, Otto Rapalino1, and Susie Huang1,2

1Radiology, Massachusetts General Hospital (MGH), Boston, MA, United States, 2Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, Charlestown, MA, United States, 3Siemens Healthineers, Shenzhen, China, 4Siemens Medical Solutions, San Francisco, CA, United States, 5Siemens Healthineers, Erlangen, Germany

We present the first large-scale evaluation of Wave-CAIPI susceptibility-weighted imaging (Wave-SWI) for clinical brain imaging. Wave-SWI was compared to conventional SWI in 107 patients undergoing 3T MRI for a range of indications in both inpatient and outpatient settings. Two neuroradiologists assessed the images in individual and head-to-head comparisons, and found no significant difference between the two sequences for detection of microhemorrhages, visualization of pathology and normal anatomy, and overall diagnostic quality, despite a nearly 5-fold decrease in acquisition time using Wave-SWI. Broader application of highly-accelerated 3D imaging may improve utilization of MRI resources while reducing motion artifacts and patient anxiety.

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