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Abstract #3136

Asymmetry of hippocampus vasculature in temporal lobe epilepsy

Rebecca Emily Feldman1, Gaurav Verma1, Stephanie Sian Gabriella Brown1, John Watson Rutland1, Madeline Cara Fields2, Lara Vanessa Marcuse2, Bradley Neil Delman2, and Priti Balchandani1

1Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

Epilepsy is a chronic and prevalent disease. When epilepsy is drug resistant, resection of epileptogenic abnormalities may control seizures. However, there exist focal epileptogenic abnormalities which are not well visualized by current imaging techniques. Hippocampal vascularity has yet to be explored as an in vivo marker for the epileptic brain. Using susceptibility weighted imaging at 7T MRI we are able to visualize vessels in the hippocampus, and have automatically segmented the vessels in the hippocampus of 19 patients with temporal lobe epilepsy and 19 healthy controls. We found significant asymmetry in the vessel density in patients with epilepsy when compared against healthy controls.

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