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Abstract #3175

Susceptibility and Volume Changes of the Mammillary Bodies as a Function of Age for Healthy Individuals and Early Stage Dementia

Zhijia Jin1, Sean K. Sethi2,3, Binyin Li4, Naying He1, Weibo Chen5, E. Mark Haacke6, and Fuhua Yan1

1Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2Magnetic Resonance Innovations, Inc., Bingham Farms, MI, United States, 3The MRI Institute for Biomedical Research, Bingham Farms, MI, United States, 4Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 5Philips Healthcare, Shanghai, China, 6Department of Radiology, Wayne State University, Detroit, MI, United States

The mammillary bodies play an important role in episodic memory and spatial memory. However, few studies have focused on their properties in humans due to the limitations of the imaging techniques, their location and small size. In this study, we evaluate brain iron content and volume of the mammillary bodies in subjects with mild cognitive impairment (MCI), Alzheimer’s Disease and healthy individuals using quantitative susceptibility mapping and 3D T1-weighted imaging. There was a slight reduction in volume and increase in susceptibility with age and there were no differences of either susceptibility or volume among the three groups.

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