We aimed to evaluate the effect of deep medullary veins (DMVs) disruption on cognition in cerebral small vessel disease (cSVD) patients and to examine whether white matter microstructure integrity mediate the relationship between DMVs disruption and cognitive impairment. Susceptibility-weighted images were used to observe characteristics of DMVs. White matter was classified into white matter hyperintensities (WMH) and normal appearing white matter (NAWM), and the average Fractional anisotropy (FA) and cerebral blood flow values of each region were extracted and compared. Mediation analyses revealed that the effect of DMVs score on cognition was mediated by microstructure integrity (FA value) in NAWM.
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