Normal pressure hydrocephalus (NPH) is a form of dementia characterized by cognitive impairment, urinary incontinence and abnormal gait. NPH can be difficult to differentiate from other dementias, but it can be treated in many cases if accurately diagnosed. Here we tested whether MR elastography-based measures of brain stiffness and damping ratio could discriminate subjects with NPH from both cognitively normal subjects and those with probable Alzheimer’s disease. Both mechanical parameters exhibited significant group-wise differences in a specific spatial pattern. Further, summary measures of these spatial patterns in individuals discriminated subjects with NPH from the other two groups (area under ROC≥0.94).