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Abstract #3186

Amyloid- β Associations with White Matter Integrity in Down Syndrome Assessed Using Diffusion Tensor Imaging and 11C-PiB Positron Emission Tomography

Austin Patrick1, Minjie Wu2, Patrick Lao3, Douglas Dean1, Matthew Zammitt1, Sterling Johnson1, Dana Tudorascu2, Annie Cohen2, Karly Cody1, Charles Laymon2, William Klunk2, Shahid Zaman4, Benjamin Handen2, Andrew Alexander1, and Bradley Christian1

1University of Wisconsin-Madison, Madison, WI, United States, 2University of Pittsburgh, Pittsburgh, PA, United States, 3Columbia University, New York, NY, United States, 4University of Cambridge, Cambridge, United Kingdom

Nearly all people with Down Syndrome will develop Alzheimer’s Dementia neuropathology by age 50, often asymptomatically. In this work, diffusion tensor imaging (DTI) was used to characterize white matter (WM) tract microstructure in thirty-three non-demented participants with Down Syndrome. Amyloid plaque burden was assessed using PET imaging with C-11 PiB. DTI measures were used to compare WM microstructure in DS individuals with high amyloid burden (PiB+) versus individuals with low amyloid burden (PIB-). PIB+ adults demonstrated significantly increased mean diffusivity and decreased fractional anisotropy in several bilateral WM regions. These findings are consistent of signs of WM degeneration.

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