A major challenge with EPI-based
diffusion-weighted imaging (dMRI) is magnetic field inhomogeneity-associated
distortion and signal loss. We implemented a mono-polar diffusion-preparation
module for TSE sequence (DP-TSE) as an alternative to achieve distortion-free,
high-resolution diffusion imaging with improved signal-to-noise ratio (SNR).
Such an approach has been demonstrated in human subjects with a promising
potential. We want to further evaluate the robustness of the implemented DP-TSE
sequence and the feasibility of applying this approach for anesthetized macaques,
and investigate whether DP-TSE is superior to alternative dMRI method in terms
of imaging quality and SNR efficiency.