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Abstract #3232

Evaluation of Neuroprotective Effects of Cyclosporine in a Porcine Model of Focal Traumatic Brain Injury using Diffusion Tensor Imaging

Nile Delso1, Michael Karlsson1,2,3,4, Bryan Pukenas5, Johannes K. Ehinger1,2,3, Sumei Wang5, Matilda Hugerth2, Eskil Elmér2,3, Suyash Mohan5, Magnus J. Hansson2,3, Todd Kilbaugh1, and Sanjeev Chawla5

1Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 2Neurovive Pharmacuetical AB, Lund, Sweden, 3Mitochondrial Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden, 4Department of Neurosurgery, Rigshospitalet, Copenhagen, Denmark, 5Department of Radiology, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA, United States

A moderate focal contusion injury model in swine was used to evaluate treatment response to cyclosporine, a neuroprotective agent, using diffusion tensor imaging. This work builds upon the recent work in which we demonstrated improved neurological outcomes after administration of cyclosporine in the acute time period following traumatic brain injury (TBI). Regions of interests were drawn on the peri-contusion regions. We observed significant elevations in FA and CL and significant decline in CS from cyclosporine groups compared to those of placebo. These findings suggest that DTI may be useful in assessing treatment response to cyclosporine in a porcine model of TBI.

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