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Abstract #3234

MRI Correlates of Neurological Outcomes in a Rat Spinal Cord Injury Model

Matthew Budde1, Natasha Wilkins1, Brian Schmit2, and Shekar Kurpad1

1Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, 2Biomedical Engineering, Marquette University & Medical College of Wisconsin, Milwaukee, WI, United States

This work evaluated the prognostic potential for quantitative MRI measures of the spinal cord compared to neurological assessments in a rat model of spinal cord injury. The results demonstrate in the acute setting, that a double diffusion encoded spectroscopy acquisition has greater accuracy than either DWI-EPI or T2 mapping while in the chronic setting, measures of spinal cord atrophy perform better than DWI measures. These results set the basis for future patient studies to improve MRI biomarkers in spinal cord injury.

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