Cerebral small vessel disease (SVD) has a long period of silent progression until it clinically manifests as a stroke or cognitive decline. Early detection of microstructural alterations in the white matter will help to develop targeted therapy and avoid clinical consequences. The need for advanced imaging to reflect the plethora of the changes is increasing. Here, we used the methods for the analysis of the diffusion MRI signal to investigate microstructural alterations in SVD. Our study identified the most frequently changed parameters and the affected regions. We also show increased changes in the diffusion MRI metrics, corresponding with disease severity.