The pulse pressure wave is an indicator for vascular health. Given the importance of vascular health to the central nervous system, we developed a method to extract intracranial pulse waveforms along the main cerebral arteries from dynamic MRI data. The resulting “pulse wave profiles” track the pulse shape along the main arteries of the brain. The simultaneous acquisition of pulse waveforms within the whole brain at once allows for a system analysis of the vasculature. A Matlab toolbox to compute pulse wave profiles is provided.