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Abstract #3274

Altered resting-state functional connectivity of primary visual cortex in young patients with comitant exotropia

Zhi Wen1, Xuefang Lu1, Xin Huang2, Yang Fan3, Yunfei Zha4, and Baojun Xie4

1Radiology, Renmin Hospital of Wuhan University, Wuhan, China, 2Ophthalmology, Renmin Hospital of Wuhan Uiversity, Wuhan, China, 3GE Healthcare, Beijing, China, 4Radiology, Renmin Hospital of Wuhan Uiversity, Wuhan, China

The comitant exotropia (CE) is a common eye disease characterized by outward deviation of the eyes and impairment of stereovision. In this study, we aim to investigate the altered functional connectivity (FC) in patients with CE using resting-state fMRI. The CE patients showed significantly less FC between the left V1 and left lingual gyrus/cerebellum posterior lobe, right MOG, left precentral gyrus/postcentral gyrus and right IPL/postcentral gyrus; as well as less FC between right V1 and right MOG (BA19, 37). Our findings show that CE involves defects in the possessing of stereovision, such as fusion, spatial processing, visual recognition, and oculormotor.

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