Maternal depression is a well-documented risk factor for psychopathology in children; the origins of this association, however, are not well understood. We present preliminary analyses of 24 infants using a multi-shell diffusion MRI sequence optimized for imaging infant white matter, along with a novel tract clustering and identification workflow, TractStat. We examine the association between maternal depressive symptoms and infant white matter organization in the uncinate fasciculus (UF). Infants whose mothers report experiencing more severe depressive symptoms have lower fractional anisotropy of the right UF, highlighting a possible neurobiological marker of the intergenerational transmission of risk for depression.
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