In order to overcome the limitations of conventional MRI in MS, we explored the ability of NODDI to characterize features of acute and chronic lesions. In our study, in line with a recent work that histologically investigated animal models, Orientation Dispersion Index (ODI) was significantly higher in enhancing lesions, thus representing a reliable tool for detecting acute inflammation. After enhancement, lesions could be divided based on their change in Neurite Density Index (NDI): lesions showing increasing NDI values were likely to be characterized by partial remyelination, whereas lesions showing decreasing NDI values might be expression of chronic focal damage.
This abstract and the presentation materials are available to members only; a login is required.