Abstract #3299

Advanced MRI in subtypes of multiple sclerosis: T1, T2, water content and diffusion basis spectrum imaging

Irene M Vavasour¹, Carina Graf^2,3, Shannon H Kolind^1,2,3,4,5, Peng Sun⁶, Robert L Carruthers⁴, Anthony Traboulsee^4,5, GR Wayne Moore^3,7, Sheng-Kwei Song⁶, David KB Li^1,4,5, and Cornelia Laule^1,2,3,7

¹Radiology, University of British Columbia, Vancouver, BC, Canada, ²Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ³International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada, ⁴Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada, ⁵MS/MRI Research Group, University of British Columbia, Vancouver, BC, Canada, ⁶Radiology, Washington University, St. Louis, MO, United States, ⁷Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

T₁, T₂, water content (WC) and diffusion basis spectrum metrics were compared from the normal appearing white matter (NAWM) of 10 clinically isolated syndrome (CIS), 27 relapsing-remitting multiple sclerosis (RRMS), 14 secondary progressive multiple sclerosis (SPMS) and 5 primary progressive multiple sclerosis (PPMS) subjects. SPMS showed higher WC, longer geometric mean T₂ and a larger hindered fraction than CIS indicating increased oedema. Fibre fraction (apparent axonal density) was lower in RRMS and SPMS than CIS thought to reflect loss of axons or increased oedema. Advanced imaging can show differences between MS subtypes related to the underlying tissue damage.

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