We developed a novel method which is applicable to visualize myelin component in the human brain using relaxation time derived from QPM-MRI. Our method demonstrated acknowledgement that the myelin content increased proportionally by times R1 and R2 in healthy volunteers. Linear regression analysis showed a strong and highly significant correlation between conventional T1w/T2w ratios and R1ยทR2* times derived from QPM (R = 0.61, P < 0.0001). In conclusion, our myelin mapping technique using QPM may replace conventional T1w/T2w ratio mapping and be expected to become independent of measurement conditions due to having quantitative characteristic of QPM itself.
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