Teriflunomide is a trifluorinated drug indicated in the treatment of multiple sclerosis (MS). Using fluorine (19F) MR methods, the biodistribution of this anti-inflammatory drug could be examined in vivo to guide pharmacological studies and dosage adjustments en route to individualized therapy. In this study, we administered teriflunomide to healthy rats and an animal model of MS. We could detect teriflunomide non-invasively in various tissues in vivo, during the disease course and ex vivo.
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