A multiparametric, quantitative method was implemented in a population-based study of normal ageing - the 1000Brains study. Several parameters are derived with whole-brain, high-resolution imaging in TA=21min: these included water content, T1 and T2* relaxation times, their changes in the presence of saturation and calculated qMT parameters - MTR, bound proton fraction fboundand forward magnetization exchange rate (kex). Methodological precision is high allowing for detecting of ageing effects as illustrated by several parameters (T1, T2*, H2O, fbound) from data sets of 25 healthy subjects (mean age 53±16 years, from 27 to 80, 18 male).
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