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Abstract #3382

Altered structural connectivity in the auditory-related pathway in patients with idiopathic sudden sensorineural hearing loss by diffusion spectrum imaging

Zihao Zhang1, Tao Jiang1, Xiuqin Jia1, Xiaojiao Guan1, Qinglei Shi2, Jing Yang3, and Yi Zhang3

1Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China, 2MR Scientific Marketing, Siemens Healthcare, Beijing, China, 3Department of Hyperbaric Oxygen, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

Sensorineural hearing loss is increasingly recognized as the result of alterations in the auditory-related network. The present study aimed to further explore the whole brain abnormalities of neural network connections in idiopathic sudden sensorineural hearing loss (ISSNHL) through diffusion spectrum imaging. It was found left-sided ISSNHL exhibited decreased connectivity between the contralateral inferior temporal gyrus and rolandic operculum, and the contralateral heschl gyrus and superior marginal gyrus; while increased connectivity was detected between the ipsilateral temporal pole and cuneus, which suggests that DSI could help investigate the structural correlates of these imaging abnormalities in this disease.

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