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Abstract #3442

Inter- and intraobserver reproducibility of two different delineation of intravoxel incoherent motion in differentiating benign and malignant thyroid nodule

Yunlong Yue1, Minghui Song1, Yanfang Jin1, Jinsong Guo1, Lili Zuo1, Queenie Chan2, and Zhenchang Wang3

1MR Department, Beijing Shijitan Hospital of Capital Medical University, Beijing, China, 2Philips Healthcare, Hong Kong, China, 3Beijing Friendship Hospital, Capital Medical University, Beijing, China

To compare the reproducibility and diagnostic performance of IVIM parameters derived from 3D whole-lesion (W-L ROI) and single-section (S-S ROI) delineation respectively . Forty-three patients with 46 pathologically confirmed thyroid nodules were involved. Reduced FOV DWI with 2D RF was employed to decrease the distortion. The ICC values of all IVIM parameters were higher with W-L ROI delineation than with S-S ROI delineation. The 95% limits of agreement (Bland-Altman plots) determined by W-L ROI revealed smaller absolute intra- and interobserver variability and the AUC of W-L ROI delineation was higher than S-S ROI according to ROC analysis.

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