Abstract #3453

Head and neck squamous cell carcinoma: diagnostic performance of diffusion kurtosis imaging for the prediction of histopathologic prognostic factors

Tong Su¹, Yu Chen¹, Zhenyu Jin¹, Xiaohua Shi², Xingming Chen³, Tao Zhang⁴, Jinxia Zhu⁵, Robert Grimm⁶, Huadan Xue¹, and Zhuhua Zhang¹

¹Radiology, Peking Union Medical College Hospital, Beijing, China, ²Pathology, Peking Union Medical College Hospital, Beijing, China, ³Otolaryngology, Peking Union Medical College Hospital, Beijing, China, ⁴Stomatology, Peking Union Medical College Hospital, Beijing, China, ⁵Siemens Healthcare Ltd., Beijing, China, ⁶Siemens Healthcare GmbH, Erlangen, Germany

This preliminary study evaluated the diagnostic efficacy of diffusion parameters, derived from different models, for differentiating between tumor grades and identifying metastatic lymph nodes in head and neck squamous cell carcinomas (HNSCCs). Superior diagnostic efficiency was achieved when combining ADC values derived from a mono-exponential model with kurtosis and diffusivity values derived from a diffusion kurtosis imaging (DKI) model compared to using each parameter by itself.

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