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Abstract #3506

In-vivo Diffusion Exchange Spectroscopy (DEXSY), to measure water exchange in tumours.

James Olav Breen-Norris1,2, Bernard Siow1,2,3, Claire Walsh1, Mark F. Lythgoe1, Andrada Ianus2, Daniel C. Alexander2, and Simon Walker-Samuel1

1Centre for Advanced Biomedical Imaging, Division of Medicine, UCL, London, United Kingdom, 2Microstructure Imaging Group, Centre for Medical Image Computing, Department of Computer Science, UCL, London, United Kingdom, 3The Francis CRICK institute, London, United Kingdom

We describe the first use of Diffusion Exchange Spectroscopy (DEXSY) in-vivo, to measure water exchange in tumours. We present preliminary data suggesting that we can capture information about the micro-structure of tumors, with what appear to be intracellular, extracellular and perfusion peaks present in diffusion-diffusion exchange plots, acquired from subcutaneous tumor xenograft models, in-vivo using DEXSY.

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