Diffusion tensor imaging (DTI) has been widely used to provide tissue microstructure measures such as fractional anisotropy (FA). Advances in diffusion acquisition methods (e.g. efficient spherical tensor encoding) have enabled more specific microstructural parameters to be derived, including microscopic fractional anisotropy (µFA). This work focused on extending our initial observation of µFA in the kidney through a detailed analysis of the linear and spherical diffusion encoding in healthy subjects, by comparing conventional FA to the µFA in human kidneys, and investigating the technical limitations of the current approach.
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