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Abstract #3532

Novel HARDI-ZOOMit protocol detects changes in spinal cord microstructure in patients with asymptomatic non-myelopathic degenerative cervical spinal cord compression

René Labounek1,2,3, Jan Valošek1,4, Tomáš Horák5,6, Alena Svátková5,7, Petr Bednařík5,8, Pavel Hok1,2, Petr Kudlička5, Magda Horáková5,6, Jan Kočica5,6, Christophe Lenglet9, Julien Cohen-Adad10, Igor Nestrašil3,9, Josef Bednařík5,6, and Petr Hluštík1,2

1Department of Neurology, Palacký University, Olomouc, Czech Republic, 2Department of Neurology, University Hospital Olomouc, Olomouc, Czech Republic, 3Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States, 4Department of Biomedical Engineering, University Hospital Olomouc, Olomouc, Czech Republic, 5Central European Institute of Technology, Masaryk University, Brno, Czech Republic, 6Department of Neurology, University Hospital Brno, Brno, Czech Republic, 7Department of Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria, 8High Field MR Centre, Medical University of Vienna, Vienna, Austria, 9Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 10Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada

Detection of degenerative cervical spinal cord compression (DCSCC) at early stage that causes spinal cord (SC) microstructure disruption is limited when current imaging techniques are used. Early detection of damage to SC can predict symptomatic degenerative cervical myelopathy (DCM). We are presenting novel HARDI-ZOOMit protocol (High Angular Resolution Diffusion Imaging + syngo ZOOMit sequence), which is able to detect changes in microstructural diffusion MRI (dMRI) parameters (e.g. fractional anisotropy – FA, mean diffusivity – MD) in asymptomatic DCSCC. Results obtained with HARDI-ZOOMit protocol reveal higher sensitivity when compared to clinical RESOLVE (REadout Segmentation Of Long Variable Echo trains) protocol.

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