Abstract #3602

Diffusion Weighted MRI Characterization of Effects of Sex and APOE Genotype in a Mouse Model

Loi Vinh Do¹, Adam Scott Bernstein¹, Aarti Mishra^2,3, Maunil K Desai², Marc Lindley¹, Chidi Ugonna¹, Nan-kuei Chen¹, Roberta Brinton^3,4, and Theodore Trouard¹

¹Biomedical Engineering, University of Arizona, Tucson, AZ, United States, ²Department of Clinical Therapeutics, USC School of Pharmacy, University of Southern California, Los Angeles, CA, United States, ³Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, United States, ⁴Department of Pharmacology, University of Arizona, Tucson, AZ, United States

Structural and diffusion MRI (dMRI) analyses can be used to characterize neurodegeneration during Alzheimer’s disease progression. Male and female mice with a targeted replacement of mouse APOE gene with humanized APOEε3 or APOEε4, underwent behavioral, transcriptomic and imaging analyses. Postmortem MRI of fixed brains included high resolution T2-weighted and diffusion weighted imaging. Structural volume assessment revealed that APOE genotype and sex have a significant impact on regional brain volumes. dMRI quantified white matter microstructural differences between APOEε3 or APOEε4 females/males which maybe cross-validated with transcriptomic and behavioral findings. Further confirmation of microstructural assessment is pending by electron micrographs.

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