In this study, diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) were used to assess brain changes in white matter regions as a result of repeated videogame training. In a cohort playing a simulated race car game, we observe evidence of microstructural changes in tracts associated with working and long-term memory. Subjects playing a guitar simulation game, experienced changes in regions associated with attention, visuomotor learning, and proprioception of the limbs. This study demonstrates that diffusion MRI is promising for characterizing subtle brain changes associated with learning.
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