Mucopolysaccharidoses (MPSs) is a group of inherited lysosomal storage disorders that could cause multiple organ failure, cognitive impairment, and shortened life span. In spite of the recognizable clinical morphological and physiological features associated with MPSs, brain connectivity changes and physiopathologic mechanisms responsible for these alterations in the central nervous system are rarely studied but might be a reliable biomarker for disease severity and treatment efficacy. A new study of brain connectome on MPS I mouse model using resting-state functional MRI (rs-fMRI) technique was conducted and a dramatic deterioration on functional connections involving multiple brain regions were observed.
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