Cannabis use is rising worldwide. Robust standardized methodologies in animal models are needed to further elucidate the impact of cannabis on overall health. Our aim was to identify acute exposure methods that provide a viable model for human cannabis consumption. C57BL/6J mice were exposed to cannabis aerosols using a Volcano® vaporizing device. Cannabis dosage levels were identified that elicited a human-like response. Animals were exposed while undergoing fMRI scans of their neurological activity. BOLD data, coupled with blood pressure and behavioral tests, demonstrated that our exposure methods generated a reproducible response that can be adapted for further studies.