Abstract #3709

The temporal stability of BOLD is improved by calibrating the cerebral vascular reactivity underpinned by the vascular probability within the group

Yi-Tien Li^1,2, Jacky Tai-Yu Lu³, Ren-Horng Wang³, Pu-Yeh Wu¹, Ying-Hua Chu¹, and Fa-Hsuan Lin^1,4,5

¹Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan, ²Department of Medical Imaging, Taipei Medical University - Shuang-Ho Hospital, New Taipei, Taiwan, ³Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, ⁴Department of Neuroscience and Biomedical Engineering, Aalto University, Espoo, Finland, ⁵Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

We hypothesize that the local venule vasculature underlies the BOLD signal latency and its variability. This hypothesis was tested by measuring the BOLD signal in the human primary visual cortex with a 10-Hz sampling rate during a visuomotor and a breath-holding (BH) task. A venule probability (VP) map was estimated by susceptibility-weighted images. We found that VP was significantly correlated to the relative BOLD latency and relative latency variability during the visuomotor task. These correlations disappeared after subtracting the latency in the BH task from the latency in the visuomotor task. These results support our hypothesis.

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