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Abstract #3727

Title: A Closer Look at the Vascular Component of Hemodynamic Response Function and Its Variations by Aging

Azin Esmaelbeigi1,2, M. Aras Kayvanrad1,2, and J.Jean Chen1,2

1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Rotman Research Institute, Baycrest Centre, Toronto, ON, Canada

It has been shown that the brain vasculature changes with aging. The unhealthy brain vasculature is associated with risks of a lot of conditions such as stroke and ischemic attacks. Moreover, some studies have confirmed the causality of the impaired vasculature and the diseases of aging such as Alzheimer’s disease. Herein, we study the effect of aging on the vascular component of the hemodynamic response function. The results demonstrated narrower and more positively skewed distributions of peak spectral power in older controls which indicate degradation in some regions of the brains of the older adults.

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