There is a pressing need to implement Thermal MR therapies in the brain, particularly to sensitize treatment of aggressive cancers like glioblastoma multiforme. Given the high power transmission regime of Thermal MR therapies, it is crucial to understand the engineering constraints affecting RF power losses, since inaccurate estimates could compromise the efficiency and precision of the therapy. Here we conducted a thorough simulation of five RF applicator designs, using realistic loss estimates of material and electrical components, and considering antenna design, position and coupling. Results from simulated and patient-derived data underscore that clinical requirements must balance with practical engineering constraints.
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