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Abstract #3878

Regional Brain Resting-State Neural Activity in Patients with Single Ventricle Heart Disease

Xiaopeng Song1, Bhaswati Roy2, Sadhana Singh1, Ashish Kaul Sahib1, Nancy Halnon3, Alan Lewis4, Mary Woo2, Nancy Pike5, and Rajesh Kumar1

1Departments of Anesthesiology, University of California Los Angeles, Los Angeles, CA, United States, 2School of nursing, University of California Los Angeles, Los Angeles, CA, United States, 3Division of Pediatric Cardiology, University of California Los Angeles, Los Angeles, CA, United States, 4Division of Pediatric Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, 5University of California Los Angeles, Los Angeles, CA, United States

Patients with single ventricle heart disease (SVHD) commonly show brain structural injuries in autonomic, mood, and cognition regulatory areas. However, whether SVHD subjects have functional impairments in these sites is unknown. We examined regional neural activity changes in SVHD patients, and found reduced regional homogeneity (ReHo) in posterior cingulate, medial prefrontal cortex, inferior parietal lobule, and left insula, and increased ReHo in bilateral middle occipital gyrus, cerebellar cortices, and left superior temporal gyrus over control subjects. These functional changes might be associated with impairments in autonomic, mood, and cognitive functions found in the condition.

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